Based on factors such as the source and location of the lesion, the treatment approach to rhegmatogenous retinal detachment varies. These methods aim to close the retinal break via laser treatment or cryotherapy. In scleral buckling, a piece of silicone is positioned on the sclera, causing an indentation that pushes the retina inward, alleviating vitreous traction. The subretinal fluid may be drained during this process.  Pneumatic retinopexy, where gas is used to reattach the retina and vitrectomy, can be a further treatment option. This is a process that involves the removal of the vitreous gel and infusion into the eye with either gas or silicone oil. The retinal injury may also be repaired by the use of laser photocoagulation with individual lasers, or cryopexy. In most cases of rhegmatogenous retinal detachment, surgery is highly effective.

When rhegmatogenous detachment is induced by vitreoretinal tension, vitrectomy is frequently used as a therapy. This growing prevalent surgery involves removing the vitreous gel and replacing it with gas (SF6 or C3F8) or silicone oil. The vitreous cavity is filled with either gas (SF6 or C3F8) or silicone oil (PDMS) after vitrectomy. A potential drawback of silicone oil is that it can cause myopia, and it must be removed within six months. Using gas, on the other hand, necessitates optimal patient positioning following surgery; the gas is absorbed within a few weeks without creating myopic changes.